A METHOD OF CURATIVE THERMORADIOTHERAPY IN SUPERFICIAL TUMORS, BREAST, HEAD AND NECK AND PROSTATE

JAMES HAIM I. BICHER, M.D., NAZAR Al-BUSSAM, M.D. and RALPH S. WOLFSTEIN, M.D.

Valley Cancer Institute, Los Angeles, California U.S.A.

Objectives:     Hyperthermia increases the response of malignant tumors to radiation therapy in experimental animals and clinical treatment.  In our experience, first in re-treatment of previously radiated fields that necessitated the use of low dose radiation fractions as adjunct to the heat treatments, and then progressively “de novo” and eventually with curative intent, treatment protocols have been devised and tested that yield positive preliminary data showing superior tumor response rates and less side effects when compared with historical controls at our institute. Based on these results and an increasing world literature we undertook to treat with curative intent superficial heatable tumors of the breast, prostate and head neck regions in patients that had refused conventional cancer therapy.

Methods:     The hyperthermia part of the protocol extends the number of heat treatments to correspond to the number of radiation-fractions. The number of hyperthermia treatments therefore varies from 25-50 per course for each treated field. The radiation protocol consists of progressively decreasing daily doses of radiation therapy. Typically the treatment is started at a daily dose of 180 cGy gradually reduced to 100 cGy protracting a typical radiation therapy treatment course from 5000 cGy in five weeks to 5000 cGy given in over eight weeks; or 7000 cGy in seven weeks to 7000 cGy in 14 weeks. According to the ELLIS TDF formula, this results in a 15% or 25% reduction of the effective radiation dose.  The total dose is adapted to the clinical situation.  To this effect, the use of objective end result parameters is introduced, including MRI, MR Spectroscopy, PET Scanning and Tumor Marker levels. Treatment is continued until these parameters revert to normal.  Forty breast patients, 27 head and neck and 18 prostate patients were treated with a follow up period of two to five years.  All patients were early stage (less than III).

Results:     Breast patients showed an 82% complete response rate, head and neck patients 88% complete response rate and prostate patients 93% complete response rate. Projected 5 year survival rates were 80% for breast patients, 88% for head and neck, and 87% for prostate patients.

Conclusion:     Protracted hyperfractionation of daily thermoradiotherapy

1          Decreases the radiation dose by 15 to 25%;

2          Decreases the side effects of radiation therapy;

3          Allows treating to effect using objective end point parameters (tumor markers, PET scans, MRI, etc.);

4          Accomplishes a high percentage of complete responses in superficial tumors;

5          Accomplishes a high 5-year survival rate in the 80-90% range in early superficial tumors;

 Keywords:    Cancer, head and neck, breast, prostate, hyperthermia, radiation, survival.

JAMES (James Haim) I. BICHER, M.D., CURRICULUM VITAE

 PERSONAL DATA

 Born: San Cristobal, Santa Fe, Argentina, May 12, 1937.

 Nationality: U.S. Citizen.

 Social Security Number: XXXXXXXXXXXX

SCHOLASTIC HISTORY

M.D. Hadassah Medical School, Jerusalem, Israel.

University of Buenos Aires Medical School  
                                          

1954‑1956

POST GRADUATE EDUCATION

Residency, Radiation Therapy 
Roswell Park Memorial Institute
Buffalo, New York
 

1976‑1977

Residency, Radiation Therapy
University of Arkansas for Medical Sciences
Little Rock, Arkansas
 

1974‑1976

Internship
Beilinson Hospital
Petah‑Tiqya, Israel
 

LICENSURE

ABR Certification in Radiation Therapy 

California Medical License  

Michigan Medical License 

New York Medical License 

Arkansas Medical License 

Arkansas Healing Arts Certificate 

 FLEX                                                                                                    

 ECFMG

Senior Consultant

Beritashvili Institute of Physiology 
Georgian Academy of Sciences
Republic of Georgia, USSR

 Director, Valley Cancer Institute

12099 W. Washington Blvd., Suite 304 
Los Angeles, California

 Chief, Hyperthermic Clinic

Western Tumor Medical Group
Van Nuys, California

 Director, Non‑Ionizing Radiation

Cancer Treatment Center
Henry Ford Hospital
Detroit, Michigan 

Associate Chief

Department of Radiation Medicine
Roswell Park Memorial Institute
Buffalo, New York

  Associate Professor Pharmacology

University of Arkansas for Medical Sciences
Little Rock, Arkansas

 Associate Professor of Anatomy and Research Medicine

Medical University of South Carolina
Charleston, South Carolina

Assistant Professor of Anatomy

Medical University of South Carolina
Charleston, South Carolina 

Associate in Anatomy

Medical University of South Carolina
Charleston, South Carolina 

Senior Scientist

Rogoff Medical Research Institute
Beilinson Hospital
Israel

 Research Supervisor

Pharmacological Screening Program

 Lecturer in Physiology and Pharmacology 

Tel Aviv University, Israel 

HONORS

 Member of National Committee on Hyperthermia.

 Founder and Past President of the North American Hyperthermia Group (NAHG).

 Travel Award, 6th International Congress of Radiation Research, 1979.

 Secretary and (1972‑1981) President (1981) of International Society of Oxygen Transport of Tissue.

 Zondec Award (Hadassah Medical School, Jerusalem), 1962. 

President and Founder of the American Society of Clinical Hyper­thermic Oncology (ASCHO).

Clinical Associate Professor in Radiology
State University of New York (SUNY)

1977‑1978

Associate Professor

Department of Biology
Wayne State University ‑ Detroit, Michigan

 Associate Professor

Department of Biology
Wayne State University ‑ Detroit, Michigan

1978‑1982

 SPECIALIZATION TRIPS

 Six (6) months ‑ Institute of Pharmacology 
Bonn University (Prof. R. Domenjoz)

 PROFESSIONAL REVIEWER OR EDITORIAL APPOINTMENTS

 Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH

 Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH

Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH

 Editorial Board of NEUROLOGICAL SCIENCES   

Editorial Board of MICROVASCULAR RESEARCH  

 Reviewer for NATIONAL SCIENCE FOUNDATION 

 Associate Editor of ENDOCURIETHERAPIE/HYPERTHERMIC 

ONCOLOGY ‑ An International Journal

1980

1978

1977 

1976

1976

1985

 Mediscience Technology, Inc. 

 Kabi‑Stockholm 

 Transidyne General Corporation

 Schering Corporation  

 Bristol Laboratories 

1971‑1972

1969‑1971

1965‑1971

1965‑1971

 PATENTS

3832994 Cardiac Monitor

 365431 Catheter System for Blood Gas Monitoring

 392065 Cardiographic Signal Processing

 370048 Blood Cell Aggregometer

 433260 External Microwave Applicator and Method

 160217 Microwave Antenna System for Intracavitary Insertion

 4369795 Implantable Microthermocouple Member

PROFESSIONAL SOCIETIES

 American Society of Therapeutic radiologists (ASTR)

 American Microcirculatory Society

 European Society of Microcirculation

 International Society on Oxygen Transport of Tissue (Past Presi­dent)

 North American Hyperthermia Group (Founder and Past President) (Currently “Society For Thermal Medicine”)

 European Society of Hyperthermic Oncology(ESHO) (Founding Member)

 Radiation Research Society

 Western Hyperthermia Group (Founder)

 American Society of Clinical Hyperthermic Oncology (Founder and President from 1985‑1986)

International Clinical Hyperthermia Society (ICHS) Founder member and past president (1999)

Current board member and American Vice-President

PUBLISHED BOOKS

 1. James Haim BICHER MD. Blood Cell Aggregation in Thrombic Processes. Ed. W Seegers, Charles C Thomas, Springfield, 1972.

 2. James Haim BICHER MD, Bruley DF, (eds). Oxygen Transport to Tissue: In­strumentation, Methods and Physiology. Plenum Press, New York, 1973.

 3. Bruley DF, James Haim BICHER MD, (eds). Oxygen Transport to Tissue: Phar­macology, Mathematical Studies and Neonatology. Plenum Press, New York, 1973.

 4. Silver I, James Haim BICHER MD, Eherecinska M, (eds). Oxygen Transport to Tissue: III. Plenum Press, New York, 1978.

 5. James Haim BICHER MD, Bruley DF. Hyperthermia. Plenum Press, New York, 1982.

 6. James Haim BICHER MD, Bruley DF. Oxygen Transport to Tissue: IV. Plenum Press, New York, 1983.

 7. Bruley DF, Reneau DD, James Haim BICHER MD. Oxygen Transport to Tissue: VII. Plenum Press, New York, 1984.

 8. James Haim BICHER MD, McLaren JR, Pigliucci GM, (eds). Consensus on Hy­perthermia for the 1990s. Clinical Practice in Cancer Treatment. Plenum Press, New York and London, 1990.

PUBLISHED BOOK CHAPTERS

 1. James Haim BICHER MD, Hetzel FW, Sandhu TS. Physiology and Morphology of Tumor Microcirculation on Hyperthermia. Chapter 9. Ed. K Storm, K Hall Publisher, New York, 1982.

 2. James Haim BICHER MD, Hetzel FW, Sandhu TS. Thermoradiotherapy in Hyper­thermia. Ed. K Storm. K Hall Publisher, New York, 1982.

PUBLICATIONS

 1. Weiman J, James Haim BICHER MD, Levi D. Application of photoconductive cell to the study of peripheral circulation in limbs of animals and men. J. Appl Physiol 1960, 15:317.

 2. James Haim BICHER MD. Description and mechanism of photoplestimographic respiratory wave in the cat. M.D. Thesis, Jerusalem, 1961.

 3. James Haim BICHER MD. A simple method for determination of systolic blood pressure in frogs. J Apl Physiol 1962, 17:173.

 4. James Haim BICHER MD, Gitter S, Manoach M, Rosen M, De Vries A. Neurotox­ic activity of Vipera palestinae venom, depression of central and cortical autonomic vasoregulatory mechanism.  Bulletin Res Coun­cil of Israel, Section F. Exp Med 1963;10:34 (Abstract).

 5. James Haim BICHER MD, Roth M, Gitter S. The influence of Vipera palesti­nae neurotoxin and of cobra venom on vegetative function in cats and on isolated nerve preparation. Israel J. Exp Med 1963, 11:206.

 6. James Haim BICHER MD, Klibansky H, Shiloach J, De Vries A, Gitter S. Pharmacological effects of electrophoretically separated frac­tions of Naja naja venom. Proc Israel Physiol and Pharmacol Soc 1965; 1:22 (Abstract).

 7. James Haim BICHER MD. Intravascular red cell aggregation (sludge) as a factor in the experimental induction of myocardial damage. Proc. Israel Physiol and Pharmacol Soc. 1965, 1:53 (Abstract).

 8. Krupnik J, James Haim BICHER MD, Gitter S. Neurotoxic effects of cobra venom. Proc of the Israel Physiol and Pharmacol Soc 1965, 7:429.

  9. Wins M, James Haim BICHER MD, Steinitz J, Rosefeld J, Gitter S. Hypopo­tassemia induced by intravenous administration of barium chlo­ride. Israel J. Med Sci 1965, 1:154.

 10. James Haim BICHER MD, Gitter s, Rosen M. On the mechanism of Vipera palestinae venom induced shock. Bibl Anat 1965, 7:429.

 11. James Haim BICHER MD, Klibansky H, Shilloach J, Gitter S, De Vries A. Isolation of three different neurotoxins from India cobra (Naja naja) venom and the relation of their action to phospholiphase. A. Biochem Pharmacol 1965, 14:1779.

 12. Roth M, James Haim BICHER MD, Gitter S. The action of Indian cobra (Naja naja) venom and its neurotoxic fractions on nerve membrane. Proc Israel and Pharmacol Soc 1966, 2:34 (Abstract).

 13. James Haim BICHER MD. Specific sites of action of snake venom in the central nervous system. International Symposium on Animal Venoms, Sao Paulo, Brazil, 1966; pg. 86 (Abstract).

 14. James Haim BICHER MD, Krupnik J, Eliash S. Pharmacological properties of 1‑6 tetrahydrocannabinol. III International Pharmacological   Congress, Sao Paulo, Brazil 1966; pg. 145 (Abstract).

 15. James Haim BICHER MD, Beemer AM. Sludge as a factor producing cardiac ischemia in atherosclerotic rabbits. Proc Israel Physiol and Pharmacol Soc 1966;2:35 (Abstract).

 16. James Haim BICHER MD, Roth M, Gitter S. Neurotoxic activity of Vipera palestinae venom ‑ depression of central autonomic vasoregulatory mechanism. Med et Pharmacol Exp 1966, 14:349.

 17. James Haim BICHER MD. Specific sites of action of snake venoms in the central nervous system. Mem Inst Butantan Simp Internac 1966; 32: 532.

 18. James Haim BICHER MD, Beemer AM. The role of sludge in production of experimental ischemic myocardial damage. Bibl Anatomica 1967; 9: 16. (Proc 4th Europ. Conf. Microcirculation. Harders H (ed) Basel: S Karger, 1966).

 19. James Haim BICHER MD, Beemer AM. Induction of ischemic myocardial damage by red cell aggregation (sludge) in the rabbit. J Atherosclerosis Res 1967, 7:409.

 20. James Haim BICHER MD. Prevention of sludge induced myocardial damage by anti‑adhesive drug. Proc V Int Conf on Microcirculation, Gothen­burg, 1968 (Abstract).

 21. James Haim BICHER MD, Licht A. K and the platelet membrane relationship to platelet aggregation and its prevention by anit‑adhesive drugs. Proc of the Internat Union of Physiol Sciences, VII, 44, 1968.

 22. James Haim BICHER MD. Effects of adrenalin infusion on platelet aggrega­tion in the cat as determined by using the screen filtration pressure method. Proc Southern Soc of Anatomists, 1968 (Abstract).

 23. James Haim BICHER MD, Meshulam R. Pharmacological effects of two active constituents of marihuana. Arch Int Pharmacodyn 1968, 172:24.

 24. Krupnik J, James Haim BICHER MD, Gitter S. Central neurotoxic effects of the venoms of Naja naja and Vipera palestinae. Toxicon 1968, 6:11.

 25. James Haim BICHER MD. Prevention by an anti‑adhesive drug of lung throm­bosis caused by blood cell aggregation. Anat Rec 1968, 163:2.

 26. James Haim BICHER MD, Licht A. The effect of adrenalin infusion of platelet aggregation in the cat as determined using the screen filtration pressure method. Pharmacol 1969, 2:209.

 27. James Haim BICHER MD. A current concept of thrombosis. Symp on Bioengi­neering. 157th meeting of the Am Chem Soc, Minneapolis, 1969.

 28. James Haim BICHER MD. 2‑Methyl‑2 tert butyl‑ketolactone, a prototype anti‑thrombic drug preventing platelet and red cell aggregation.   Circ Res 1969, 39‑49, Suppl. III:2.

 29. James Haim BICHER MD. Prevention of sludge induced myocardial damage by an anti‑adhesive drug. Bibl Anat 1969, 10:202.

 30. Nuriel EH, James Haim BICHER MD, Veanderlns E. The influence of various colloids on blood cell aggregation in vivo, as determined by the screen filtration pressure method. Biorrheology 1969, 6:65.

 31. James Haim BICHER MD, Knisely MH. Effect of circulation changes on cerebral oxygenation as determined with a new ultramicro oxygen electrode. Fred Proc 1970, 29:2 (Abstract).

 32. James Haim BICHER MD. The "membrane capacitance" aggregometer. A new method able to detect platelet aggregation in whole blood. Proc VI Conf on Microcirculation. Aalborg, Denmark 1970, 137:(Ab­stract).

 33. Ogilvie RW, James Haim BICHER MD. In vivo demonstration of several of a dextran induced sludge. Proc of VI Conf on Microcirculation. Aalborg, Denmark, 1970, 162 (Abstract).

 34. Reneau DD, Bruley DF, James Haim BICHER MD, Knisely MH. A mathematical simulation of the simultaneous difussion of oxygen and glucose in the capillaries and tissues of the human brain. Proc VI Interna­tional Conf on Microcirculation. Aalborg, Denmark, 1970, 165 (Abstract).

 35. James Haim BICHER MD, Knisely MH. Brain tissue reoxygenation time, demonstrated with a new ultramicro oxygen electrode. J Appl Physiol 1970; 28:387-390.

 36. James Haim BICHER MD. Anti‑thrombic effect of a heparin like substance (SP 54) preventing red cell and platelet aggregation. Arznelmit­telforschung (Drug Research) 1970, 20:379.

 37. James Haim BICHER MD, Reneau DD, Knisely MH. Brain tissue oxygenation as determined with a new ultramicro oxygen electrode. Hershey D (ed). Blood oxygenation. New York: Plenum Press, 1970, 201‑ 217.

 38. Reneau DD, James Haim BICHER MD, Knisely MH. A mathematical analysis predicting cerebral tissue reoxygenation time as a function of the rate of change of effective cerebral blood flow. Hershey D (ed). Blood Oxygenation. New York: Plenum Press, 1970, 175‑ 200.

39. James Haim BICHER MD. 2‑methyl‑2‑tert butyl‑ketolactone, an anti‑adhe­sive drug preventing platelet and red cell aggregation. Pharmacol 1970, 4:152.

 40. James Haim BICHER MD. A concept of anti‑thrombic therapy based on the pharmacological effects of drugs preventing platelet and red cell aggregation. Proc of the Second International Symposium on Arthe­rosclerosis. Jones R (ed). New York: Springer‑Verlag, 1970, 538.

 41. Levi J, James Haim BICHER MD, Rozenfeld JB. Platelet aggregation in several cardiovascular diseases determined with a modified screen filtration pressure method. J Med 1970, 1:132.

 42. James Haim BICHER MD. Anti‑adhesive drugs in thrombosis. Throm et Diath Haem 1970; suppl 42:197.

 43. James Haim BICHER MD. Reneau DD, Bruley DF, Knisely MH. Changes in brain tissue oxygenation during acute hypoglycemia as determined with oxygen ultramicro electrode and on‑line computer simulation. Proc of Internat Union of Physiological Sciences, Vol. IX, 1971 (Abstract).

 44. James Haim BICHER MD, Beemer A. Prevention by anti‑adhesive drug of thrombosis caused by blood cell aggregation. Angiol 1971, 21:413.

 45. Reneau DD, Reardon WR, James Haim BICHER MD, Bruley DF, Knisely MH. On line computer simulation of oxygen response in brain during anoxic‑anoxia and hypoglycemia. Biomedical Engineering‑Computer Simulation Symposium. Am I Ch E J 1970; 20.

 46. James Haim BICHER MD. The "membrane capacitance" aggregometer. A method for measuring platelet aggregation in whole blood. Angiol 1971, 22:285.

 47. James Haim BICHER MD, Bruley DF, Reneau DD, Knisely MH. Effect of in­travascular red cell aggregation and its counteraction by anti‑ adhesive drugs on brain tissue oxygenation. Proc 6th Europ Conf Microcirculation. Ditzel J, Lewis DH (eds). Basel: S Karger, 1971, 193.

 48. James Haim BICHER MD, Reneau DD, Bruley DF, Knisely MH. Effect of micro­circulation changes on brain tissue oxygenation. J Physiol 1971, 217:689.

  49. Dougherty W, James Haim BICHER MD. The effects of anti‑adhesive agents on the ultrastructure of rabbit blood platelets in vivo. Throm Diath Haem 1971; XXVI, 2:378.

 50. James Haim BICHER MD, Fitts CT, Yarbrough DY. Effect of norepinephrine, blood sludging and respiratory gas change on blood and tissue oxygenation as determined with ultramicro oxygen electrodes. Surg Forum 1971, 22:213.
 

 51. Reneau DD, Knisely MH, James Haim BICHER MD, Bruley DF. Glucose diffu­sion and consumption in the human brain, Part I: Literature review and mathematical development. Transport Processes in Biology and Medicine, 70th National Meeting of AIChE. Atlantic City, NJ, 1971.

52. Reneau DD, Knisely MH, James Haim BICHER MD, Bruley DF. Glucose diffu­sion and consumption in the human brain, Part II: A steady‑state mathematical simulation of glucose transport in cerebral cortex.   Transport Processes in Biology and Medicine, 70th National Meet­ing of AIChE. Atlantic City, NJ, 1971.

 53. Bruley DF, Reneau DD, James Haim BICHER MD, Knisely MH. Modeling cere­bral tissue oxygenation. Proc Workshop on Oxygen Transport in Tissue. Dortmund, Germany, 1971.

 54. Bruley DF, James Haim BICHER MD, Reneau DD, Knisely MH. Autoregulatory phenomena related to cerebral tissue oxygenation. Chemical Engi­neering Progress. Symposium Series, 1971, 67:195.

 55. James Haim BICHER MD, Ohki S. Intracellular pH electrode; experiments on the giant squid axon. Biochim et Biophysica Acta 1972, 255:900.

 56. Malcolm R, James Haim BICHER MD, Duncan RC, Knisely MH. Behavioral effects of erythrocyte aggregation. Microvascular Res 1972, 4:94.

 57. McCracken A, Bruley DF, Reneau DD, James Haim BICHER MD, Knisely MH. A systems analysis for the simultaneous diffusion of oxygen, carbon dioxide, and glucose in the capillaries and tissues of the human brain. Transactions of the First Pacific Chemical Engineering Congress. Kyoto, Japan, 1972,  137.

 58. Reneau DD, Bruley DF, James Haim BICHER MD, Knisely MH. Simultaneous diffusion of oxygen and glucose in brain. Transactions of the First Pacific Chemical Engineering Congress. Kyoto, Japan, 1972, 132.

 59. Bruley DF, Reneau DD, James Haim BICHER MD, Knisely MH. Studies of cerebral tissue oxygenation and related auto‑regulation. Advances in Chemistry Series, No. 118, Chem Engineering in Medicine 1973, 2.

 60. James Haim BICHER MD, Reneau DD, Bruley DF, Knisely MH. Brain oxygen supply and neuronal activity under normal and hypoglycemic condi­tions. Am J. Physiol 1973, 224:275-282.

 61. Reneau DD, James Haim BICHER MD, Bruley DF, Knisely MH. On line computer simulation of oxygen response in brain during anoxic anoxia. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwar­zenberg, 1973, 40.

 62. James Haim BICHER MD, Bruley DF, Reneau DD, Knisely MH. Regulatory mechanisms of brain oxygen supply. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwarzenberg, 1973, 181.

 63. Bruley DF, Reneau DD, James Haim BICHER MD, Knisely MH. Modeling cerebral tissue oxygenation with autoregulation. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwarzenberg, 1973, 30.

 64. James Haim BICHER MD. Autoregulation of oxygen supply to  brain tissue. James Haim BICHER MD, Bruley DF (eds). Oxygen Transport to Tissue: Instru­mentation, methods and physiology. New York: Plenum Press, 1973, 215.

 65. James Haim BICHER MD, Bruley DF, Knisely MH. Anti‑adhesive drugs and tissue oxygenation. Bruley DF, James Haim BICHER MD (eds). Oxygen Transport to Tissue: Pharmacology, mathematical studies and neonatology. New York: Plenum Press, 1973, 657-660.

 66. James Haim BICHER MD, Rubin JW, Adams R. Clinical use of a new intra‑ arterial catheter electrode system. Bruley DF, James Haim BICHER MD (eds). Oxygen transport to tissue: instrumentation, methods, and physi­ology. New York: Plenum Press, 1973, 107-112.

 67. Hunt DH, Bruley DF, James Haim BICHER MD, Knisely MH. Distributed model solution techniques for capillary tissue systems. Bruley DF, James Haim BICHER MD (eds). Oxygen transport to tissue: pharmacology, mathe­matical studies and neonatology. New York: Plenum Press, 1973, 887-891.

 68. Bruley DF, Hunt DH, James Haim BICHER MD, Knisely MH. Simulating myocar­dium oxygen dynamics. Bruley DF, James Haim BICHER MD (eds). Oxygen trans­port to tissue: pharmacology, mathematical studies and neonatolo­gy. New York: Plenum Press, 1973, 859-862.

 69. Fitts CT, James Haim BICHER MD, Yarborough D. Blood and tissue oxygena­tion during hemorragic shock as determined with ultramicro oxygen electrodes. James Haim BICHER MD, Bruley DF (eds). Oxygen transport to tissue: instrumentation methods and physiology. New York: Plenum Press, 1973, 447-451.

 70. James Haim BICHER MD, Reneau D, Bruley DF, Knisely MH. Autoregulation of oxygen supply to microareas of brain tissue under bypoxic and hyperbaric conditions. Bibl Anat 1973, 11:526.

 71. Reneau DD, Slack TL, Bruley DF, James Haim BICHER MD, Knisely MH. A systems analysis of oxygen and glucose transport in the human brain under conditions of countercurrent capillary blood flow. Bibl Anat 1973, 11:520.

 72. Bruley DF, Reneau DD, Knisely MH, James Haim BICHER MD. Theoretical studies of brain tissue oxygenation considering the deoxygenation rate of red cells. Bibl Anat 1973, 11:507.

 73. Bruley DF, James Haim BICHER MD, Reneau DD, Knisely MH. Autoregulation of chemotransport to brain tissue. Iberall AS, Guyton AC (eds). Regulation and control in physiological systems. Instrument Society of America, 1973, 501‑502.

 74. James Haim BICHER MD, Kuperminc M. Platelet aggregation in hyperadhesive states. Clinical Parmacol and Therap 1974, 15:604.

 75. Groome L, Bruley DF, James Haim BICHER MD, Hunt DH. Simulating physio­logical systems pseudo dynamics. Summer Computer Simulation Conference. Houston, Texas, July, 1974 (Abstract).

 76. James Haim BICHER MD. Brain oxygen autoregulation: A protective reflex to hypoxia? Microvascular Res 1974, 8:291.

 77. James Haim BICHER MD, Padilla F, Van Wagner WH. Effect of anti‑adhesive drugs on red cell sickling in vivo. Bibl Anat 1975, 13:127.

 78. James Haim BICHER MD, Hunt DH, Flake WE, Bruley DF. Autoregulatory mechanisms controlling the supply of oxygen to microareas of brain tissue. Bibl Anat 1975, 13:137.

 79. Bruley DF, Groome L, Hunt DH, James Haim BICHER MD. Predicting oxygen supply to brain tissue using a pseudo dynamic model simulation technique. Bibl Anat 1975, 13:139.

 80. James Haim BICHER MD, Hunt DH, Flacke WE, Bruley DF. Autoregulatory mechanisms controlling the supply of oxygen to microareas of brain tissue. Biochemistry an Experimental Biology 1974; 75; 11:155‑161.

 81. Eden G, Inbar GF, Timor‑Tritsch I, James Haim BICHER MD. Miniaturized electrodes for on‑line po2 measurements. Trans Biomed Eng 1975, 22:275.

 82. Bruley DF, Groome L, James Haim BICHER MD, Knisely MH. Stochastic model­ing of the brain microcirculation. Proc of First World Congress for Microcirculation. Toronto, June, 1975 (Abstract).

 83. James Haim BICHER MD, Bruley DF. Pharmacological control O2 autoregula­tion in brain tissue. Proc of First World Congress for Microcir­culation. Toronto, June 1975 (Abstract).

 84. James Haim BICHER MD, Dalrymple GC, Harris D. Effect of ionizing radia­tion on liver microcirculation: Suppression of O2 autoregulation as a possible coadjuvant to radiation therapy. Proc of Symp on Vascular Physiol to Tumors. Buffalo, June, 1975 (Abstract).

 85. James Haim BICHER MD, Ashbrook D, Harris D, Dalrymple GV. Changes in platelet and microcirculation function induced by ionizing radia­tion to the liver. Internat J. Radiat Oncol Biol Phys 1976; 1:679‑685.

 86. James Haim BICHER MD, Marvin P. Pharmacological control of local oxygen regulation mechanisms in brain tissue. Stroke 1976, 7:469‑427.

 87. James Haim BICHER MD, Bruley DF. 13.3 pharmacological control of O2 autoregulation in brain tissue. Microcirculation 1976, 1:386‑387.

 88. James Haim BICHER MD, Marvin P, Hunt D, Bruley DF. Autonomic and pharma­cological control of oxygen autoregulation mechanisms in brain tissue. Grote, Jurgen, Thews, Gerhard (eds). Oxygen transport to tissue II. New York: Plenum Press, 1977, 383‑389.

 89. James Haim BICHER MD, Dalrymple GV, Ashbrook D, Smith R, Harris D. Autonomic and pharmacological control of oxygen autoregulation mechanisms in brain tissue. Grote, Jurgen,

Thews, Gerhard (eds). Oxygen transport to tissue II. New York: Plenum Press, 1977, 497‑503.

 90. James Haim BICHER MD, Modern methodology in the study of microphysiolog­ic functions. Experta Medica International Congress Series No. 399 Anesthesiology. (IBSN) 90 219 0327 0, 1977, 488‑492.

 91. Doss LL, Kaufman N, James Haim BICHER MD. Prevention of brain tissue hypoxia by intrathecal injection of oxygenated fluorocarbon. Microvascular Research 1977, 13:253‑260.

 92. James Haim BICHER MD, Bruley DF. Interaction of alpha adrenergic block­ade and CO2 effects on the regulation of tissue O2 levels in brain. Bibl Anat 1977, 16:350‑354.

 93. James Haim BICHER MD, Kaufman N. Flow improvers prevention of microcir­culation changes induced by ionizing radiation to the liver. Bibl Anat 1977, 16:341‑344.

 94. Doss LL, Kaufman J, James Haim BICHER MD. Protective effect of intrathe­cal fluorocarbon injection on the fall of cerebral TpO2 induced by anoxic anoxia. Bibl Anat 1977, 16:412‑415.

 95. James Haim BICHER MD, Hetzel FW, D'Agostino L, Johnson RJ. Changes in tumor tissue oxygenation induced by microwave hyperthermia. Int J. Radiat Oncol Biol Phys 1977, S‑2:157.

 96. Hetzel FW, James Haim BICHER MD, Henderson B, Johnson R. Cellular respi­ratory inhibitors as hypoxic cell sensitizers. Proc of the Gray Conference, Cambridge, England, 1977 (Abstract).

 97. Johnson RJR, James Haim BICHER MD, Hetzel FW, Sandhu TS, Kowal HS. The use of either regional or whole‑body hyperthermia as an adjunc­tive treatment with radiotherapy. Proc of Conf on Clinical Pros­pects of Hypoxic Cell Sensitizers and Hyperthermia, Madison, September, 1977, 324‑329.

 98. Hetzel FW, James Haim BICHER MD, Henderson BW, Kaufman N, Brown M, Mesinger M. Chemotherapeutic drugs and radiation: Sensitization by Reoxygenation. Radiat Res 1978 (Abstract).

 99. Hetzel FW, James Haim BICHER MD, Kaufman N, Brown M, Henderson BW. Cellular respiratory inhibition by chemotherapeutic drugs as possible adjuvant to radiation therapy. Fed Proc 1978.

 100. James Haim BICHER MD. Increase in brain tissue oxygen availability induced by localized microwave hyperthermia. Silver I, Eherecin­ska M, James Haim BICHER MD (eds). Oxygen Transport to Tissue III. New York: Plenum Press, 1978, 347-352.

 101. James Haim BICHER MD, D'Agostino L, Doss LL, Kaufman N, Amigone J. Prevention of ionizing radiation induced by liver microcircula­tion changes by the use of flow improvers. Silver I, Eherecinska M, James Haim BICHER MD (eds). Oxygen Transport to tissue III. New York: Plenum Press, 1978, 383.

 102. Bruley DF, Kreisman N, James Haim BICHER MD. Mathematical models for the prediction of oxygen tension and local metabolic rate in epileptic foci. Bibl Anat.1977, 16:511-515.

 103. Johnson R, Sandhu TS, Hetzel FW, Song SY, James Haim BICHER MD, Kowal H. A pilot study to investigate skin and tumor thermal enhance­ment ratio of hyperthermia (41.5 ‑ 42C) with radiation. Int J. Radiat Oncol Biol Phys 1979, 5:947‑953.

 104. James Haim BICHER MD, Hetzel FW, Mitagvaria N, O'hara M. Reoxygenation induced by localized microwave hyperthermia as an adjuvant to radiation therapy. 6th International Congress of Radiation Re­search, 1979, 5:171-175.

105. James Haim BICHER MD, Sandhu TS, Hetzel FW. Hyperthermia as a radiation adjuvant: An effective fractionation regime. Int. J. Radiat Oncol Biol Phys 1979; 171.

 106. Hetzel FW, James Haim BICHER MD, Kaufman N, Brown M, Mensinger M. Combined chemotherapy agents and radiation: A superadditive effect. Int J. Radiat Oncol Phys 1979, 5:195.

 107. James Haim BICHER MD, Hetzel FW, Sandhu TS. Physiological and clinical effects of microwave hyperthermia. Advances in Engineering 1979; 139.

 108. Hetzel FW, James Haim BICHER MD, Sandhu TS, Kaufman N, Brown M. Supe­radditive effects in vitro combining alkylating agents and radia­tion. 6th International Congress of Radiation Research, 1979, 248.

 109. Sandhu TS, James Haim BICHER MD, Hetzel FW. Realistic hyperthermia dosimetry with blood simulation. 6th International Congress of Radiation Research, 1979, 124 (abstract).

 110. James Haim BICHER MD, Sandhu TS, Hetzel FW. Hyperthermia and radiation in combination. Int J. Radiat Oncol Biol Phys 1980, 6:867‑870.

 111. James Haim BICHER MD, Hetzel FW, Sandhu TS, Frinak S, Vaupel P, O'Hara MD, O'Brien T. Effects of hyperthermia on normal and tumor mi­croenviroment. Radiology 1980, 137:523‑530.

 112. James Haim BICHER MD. The physiological effects of hyperthermia. Radi­ology; 1980:511‑513. 

113. Sandhu TS, James Haim BICHER MD, Hetzel FW. A thermal dosimetry system with blood flow simulation. Journal of National Cancer Institute, 6:361-363.

 114. James Haim BICHER MD, Sandhu TS, Vaupel P, Hetzel FW. The effect of localized microwave hyperthermia on physiological responses. Journal of National Cancer Institute, 6:375-377.

 115. Sandhu TS, James Haim BICHER MD, Hetzel FW. A realistic thermal dosime­try system (Meeting Abstract). Third International Symposium: Cancer Therapy by Hyperthermia, Drugs and Radiation. June 22‑26, 1980, Fort Collins, Colorado. Colorado State University 1980, 152.

 116. James Haim BICHER MD, Sandhu TS, Hetzel FW. Inhomogenities in oxygen and pH distributions in tumors. Radiat Res 1980, 83‑376.

 117. Hetzel FW, Kaufman N, Brown M, James Haim BICHER MD. Indirect sensiti­zation by drug induced reoxygenation in spheroids. Radiat Res 1980, 83:375‑376.

 118. Kaufman N, Hetzel FW, James Haim BICHER MD. The effect of hyperthermia on oxygen distribution in spheroids. Radiat Res 1980, 83:395.

 119. James Haim BICHER MD, Sandhu TS, Hetzel FW. Hyperthermia fractionation protocol: Preliminary results of a clinical trial. Presented at the Third International Symposium on Cancer Therapy by Hyperther­mia, Drugs and Radiation. Fort Collins, Colorado, June 22‑26, 1980.

 120. James Haim BICHER MD, Sandhu TS, Vaupel P, Hetzel FW. Physiological mechanisms of action of localized microwave hyperthermia. Pre­sented at the Third International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 19‑20, 1980.

 121. James Haim BICHER MD, Sandhu TS, Hetzel FW, Matvia F. An effective fractionation protocol for the clinical use of hyperthermia with adjuvant radiation. Presented at the Second Meeting of the Euro­pean Group on Hyperthermia in Radiation. Rome, Italy, September 19‑20, 1980.

 122. James Haim BICHER MD, Sandhu TS, Hetzel FW, Matvia F. The clinical use of intracavitary antennae in the treatment of deep seated tumors with microwave induced hyperthermia. Presented at the American Society of Therapeutic Radiologists (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21‑25, 1980.

 123. James Haim BICHER MD, Sandhu TS, Hetzel FW. Fractionated hyperthermia in combination with radiation: Clinical results. Presented at (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21‑25, 1980.

 124. Hetzel FW, Kaufman N, James Haim BICHER MD. Oxygen distribution in spheroids: Effects of hyperthermia and drugs. Presented at the (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21‑25, 1980.

 125. Kaufman N, James Haim BICHER MD, Hetzel FW. A system for studying spheroid microphysiology. Presented at the International Work­shop/Conference on Spheroids in Cancer Research, Rochester, New York, June 16‑20, 1980.

 126. Kaufman N, James Haim BICHER MD, Hetzel FW. Measuring pO2 in spheroids during hyperthermia. Presented at the International Workshop/ Conference on Spheroids in Cancer Research. Rochester, New York, June 16‑20, 1980.

 127. Kaufman N, James Haim BICHER MD, Hetzel FW, Brown M. A system for determining the pharmacology of indirect radiation sensitizer drug on multicellular spheroids. Cancer Clinical Trials 1981; IV: 199‑204.

 128. James Haim BICHER MD, Vaupel P, O'Hara MD, O'Brien T, Mitagvaria N. Tissue oxygenation in normal and hyperthermic conditions. In proceedings of the XXVIIIth International Congress of Physiologi­cal Sciences. Budapest, Hungary, July 13‑18, 1980. Akademial Kiado Publishers: Adv. Physiol Sci. 1981, 25:215‑233.

 129. Hetzel FW, Brown M, Kaufman N, James Haim BICHER MD. Radiation sensi­tivity modification by chemotherapeutic agents. Cancer Clinical Trials 1981, IV:177‑182.

 130. James Haim BICHER MD, Hetzel FW, Vaupel P, Sandhu TS. Microcirculation modification by localized microwave hyperthermia and hematopor­phyrin phototherapy. Bibl Anat 1981, 20:628‑632.

 131. James Haim BICHER MD, Sandhu TS, Hetzel FW. Clinical thermoradiotherapy Henry Ford Hospital Med. J. 1981, 29:9‑15.

 132. James Haim BICHER MD, Mitagvaria N. Circulatory responses of malignant tumors during hyperthermia. Microvascular Research 1981, 21:19‑26.

 133. James Haim BICHER MD. Status of ongoing clinical trials with microwave hyperthermia. Brit J. Cancer 1982, 45:247‑248.

 134. James Haim BICHER MD. Hyperthermia, clinical results. In progress in Radio‑Oncolgy II. 409‑413 (ed). K.H. Karcher, Raven Press, New York, 1982.

 135. James Haim BICHER MD, Hetzel FW, Sandhu TS. Results of a phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Adv Exp Med Biol 1982, 157:87‑97.

 136. Busch NA, Bruley DF, James Haim BICHER MD. Computer modeling of tumor hyperthermia (a dynamic lumped parameter model). Adv Exp Med Biol 1982, 157:185‑189.

 137. Busch NA, Bruley DF, James Haim BICHER MD. Identification of viable regions in "in vivo" spheroidal tumors: a mathematical investiga­tions. Adv Exp Med Biol 1982, 157:1‑7.

 138. James Haim BICHER MD, Sandhu TS, Vaupel P, Hetzel FW. Effect of local­ized microwave hyperthermia on physiological responses. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:217‑219.

 139. Vaupel P, Frinak S, Mueller‑Klieser W, James Haim BICHER MD. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:207‑209.

 140. James Haim BICHER MD, Hetzel FW, Sandhu TS. Results of phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Advances in Experimental Medicine and Biology, 157: 87‑97, 1983.

 141. James Haim BICHER MD, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D, Syed N. A method of interstitial thermoradiotherapy. (Meeting Abstract). Fift Mid‑Winter Meeting of the American Endocurie­therapy Society, December 8‑10, 1982, Key Biscayne, Florida. American Endocurietherapy Society; 50, 1982. 

142. James Haim BICHER MD, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D. A system for hyperthermia retreatment of radiation failures in a free standing radiation therapy center. (Meeting abstract). Thirty‑First Annual Meeting of the Radiation Research Society, February 27 ‑ March 3, 1983, San Antonio, Texas, Radiation Re­search, 145, 1983.

 143. James Haim BICHER MD, Metcalf DR, Frey HS, Lewinsky BS, Fingerhut AG, Bruley DF. Comparative thermometry studies using microthermocou­ples and optic probes. The microcirculation factor (Meeting abstract). Thirty‑First Annual Meeting of the Radiation Research Society, February 27‑March 3, 1983, San Antonio, Texas. Radiation Research, 145, 1983.

 144. Gonzalez‑Vazquez HE, Bruley DF, James Haim BICHER MD. Distributed parameter model of temperature gradients in tumor tissue during hyperthermia with uniform heat source and nonuniform blood flow. (Meeting abstract). Thirty‑First Annual Meeting of the Radiation Research Society, February 27‑March 3, 1983, San Antonio, Texas. Radiation Research, 145, 1983.

 145. Henderson BW, James Haim BICHER MD, Johnson RF. Loss of vascular fibri­nolytic activity following irradiation of the liver ‑ An aspect of late radiation damage. Radiation Research, 95:646‑652, 1983.

 146. James Haim BICHER MD. Impact of microcirculation and physiologic con­siderations on clinical hyperthermia. Proceedings 13th Interna­tional Cancer Congress, 235‑245, Alan R Liss Inc., New York, 1983.

 147. James Haim BICHER MD. The set‑up of state of the art hyperthermia clinic‑therapeutic, ethical and practical considerations. Fron­tiers in Radiation Therapy Oncology, 18:153‑161;1984.

 148. James Haim BICHER MD, Wolfstein RS. Microwave hyperthermia as an adju­vant to radiation therapy. Summary experience of 208 multifrac­tion treatment cases. Proceedings of the 4th International Sympo­sium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:363‑366, 1984.

 149. James Haim BICHER MD, Wolfstein RS, Fingerhut AG, Frey HS, Lewinsky BS. An effective fractionation regime for interstitial thermoradio­therapy. Preliminary clinical results. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:575‑578, 1984.

 150. James Haim BICHER MD, Wolfstein RS, Fingerhut AG, Lewinsky BS, Frey HS. Clinical multified controlled comparison of the hyperthermia and low dose radiation to full dose radiation of chest wall recur­  rence. Proceedings of the 4th International Symposium on Hyper­thermic Oncology, Taylor and Francis LTD, London and Philadel­phia, 1:391‑394, 1984.

151. James Haim BICHER MD, Mitagvaria NP. Changes in tumor tissue oxygena­tion during microwave hyperthermia clinical relevance. Proceed­ings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:169‑172, 1984.

 152. James Haim BICHER MD, Moore DW, Wolfstein RS. A method for interstitial thermoradiotherapy. Proceedings of the 4th International Symposi­um on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:595‑598, 1984.

 153. Afuwape SA, Bruley DF, James Haim BICHER MD. Parameter identification of silastic tumor‑analog during thermometry control experience in hyperthermia. (Meeting abstract) 4th North American Hyperthermia Group, March 23‑27, 1984, Orlando, Florida.

 154. Gonzalez‑Vasquez HE, Bruley DF, James Haim BICHER MD. Three dimensional reconstruction of temperature profiles in tumor phantoms. (Ab­stract) 4th North American Hyperthermia Group, March 23‑27, 1984, Orlando, Florida.

 155. James Haim BICHER MD, Dujovny H, Codas C, Honig S. Effect of DMSO and barbiturates on brain oxygen distribution. Oxygen transport to tissue, Vol V, edited by D.W. Lubbers, H. Acker, E. Leniger‑ Follert, and TK Goldstick. Plenum Press, 1984, 180:332-387.

 156. James Haim BICHER MD. Hyperthermia, radiation and cancer microenviron­ment. (Meeting Abstract). 1983 International Society on Oxygen Transport to Tissue Meeting, August 16‑19, 1983, Ruston Louisi­ana.

 157. James Haim BICHER MD, Mitagvaria NP. Changes in tumor tissue oxygena­tion during microwave hyperthermia clinical relevance. Advances in Experimental Medicine and Biology, 180: 190‑905, 1985.

 158. Mitagvaria NP, James Haim BICHER MD. Effect of microwave radiation on local blood flow and tissue oxygenation in the brain. Bulletin of Experimental Biology and Medicine, 98:895‑897, 1984.

 159. James Haim BICHER MD, Moore DW, Wolfstein RS. Air‑cooled 300MHz appli­cators used in a parallel opposed phase system (POPAS). Int. J. Radiat Oncol Biol Phys, 11:S‑1:217, 1985.

160. James Haim BICHER MD, Wolfstein RS, Moore DW. A method for Interstitial thermoradiotherapy preliminary clinical results. Endocurie, Hyperthermia Oncology, 1:136, 1985. (Abstract).

 161. James Haim BICHER MD, Wolfstein RS. Local hyperthermia for deep tumors, experience with three techniques. J. Microwave Power 1986; 21st International Microwave Power Symposium Summaries:103.

 162. James Haim BICHER MD, Wolfstein RS, Lewinsky BS, Frey HS, Fingerhut AG.  Microwave hyperthermia an adjunct to radiation therapy: Summary experience of 256 multifraction treatment cses. Int J Rad Onc Biol Phys 1986, 12:1667‑1671.

 163. James Haim BICHER MD, Afuwape SA, Bruley DF. A Three dimensional axisy­metrical finite element method (FEM) of microwave energy deposi­tion in biological media. (Abst.) 7th Annual Meeting, North American Hyperthermia Group, February 21‑26, 1987.

 164. Kang KA, Bruley DF, James Haim BICHER MD. A computer simulation of simultaneous heat and oxygen transport during heterogeneous three dimensional tumor hyperthermia. Adv. Exp. Med. Biol. 1987, 3:455-451..

 165. James Haim BICHER MD, Shani J, Reesman KJ. Use of non perturbing ther­mocouples (NPT's) for hyperthermia clinical thermometry. Int. J. Hyperthermia, 3:550‑551, 1987. (Abst) and J. Microwave power 22: 173, 1987, (Abst).

 166. James Haim BICHER MD, Wolfstein RS, Chatham PL. Hyperthermic adjunct treatment for specific sites: nasopharynx, pancreas, liver, chest and pelvis. Preliminary experience. Int. J. Hyperthermia 3:551, 1987 (Abstract).

 167. James Haim BICHER MD, Afuwape SA. Mathematical prediction and phantom studies of the clinical target "Hot spot" using a three applica­tor phased array system (TRIPAS). Int. J. Hyperthermia 3:550, 1987 (Abstract).

 168. James Haim BICHER MD, Afuwape SA, Bruley DF. Reesman KJ, Wolfstein RS. Mathematical prediction and phantom studies of the clinical "Hot spot" using a three applicator phased array system (TRIPAS). Amer. Soc. Mech. Eng. Symposium on Hyperthermia, December 13‑18, 1987.

 169. James Haim BICHER MD, Afuwape SA. A three applicator microwave phased array system (TRIPAS). Featuring mathematical prediction and relocation of the hyperthermia clinical target "Hot spot". J. Microwave Power, 22:173-178, 1987.

 170. James Haim BICHER MD, Wolfstein RS. Local Hyperthermia of tumors at moderate depth using POPAS: Results by site (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:16‑21, 1988.

 171. James Haim BICHER MD, Shani J, Reesman KJ. Use of non‑perturbing ther­mocouple for clinical hyperthermia thermometry (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:16‑21, 1988.

 172. James Haim BICHER MD, Wolfstein RS. Treatment of intratoracic lesions. Preliminary results (Abstract). 37th Annual Meeting of the Radia­tion Research Society. 3:18‑23, 1989.

 173. James Haim BICHER MD, Reesman KJ. Use of conductive thermoplastic wires as oxygen sensors in microwave fields (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:18‑23, 1989.

 174. James Haim BICHER MD, Wolfstein RS. Hyperthermia treatment for abdomi­nal tumors (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:18‑23, 1989.

 175. James Haim BICHER MD, Wolfstein RS. Local superficial and deep hyper­thermia. Factors affecting tumor response and patient survival (Abstract). 37th Annual Meeting of the Radiation Research Socie­ty, 3:18‑23, 1989.

 176. James Haim BICHER MD, Reesman KJ, Afuwape SA. A target triapplicator system with non‑perturbing thermocouples thermometry. Hyperther­mic Oncology 1988, Taylor and Francis, 1:778‑779, 1989. 

 177. James Haim BICHER MD, Wolfstein RS. Hyperthermia palliation of bone pain (Abstract). The 13th International Symposium on Clinical Hyperthermia, 5:21‑25, 1990.

 178. James Haim BICHER MD, Hileman D, Moore D, Caridad C. Use of Pi‑Network tuners in non‑contact hyperthermia applicators (Abstract). The 13th International Symposium on Clinical Hyperthermia 5/21‑25, 1990.

 179. James Haim BICHER MD, Wolfstein RS. More treatments prove better ther­motolerance ? (Abstract). 11th Conference of the European Society for Hyperthermia Oncology, 9:17‑20, 1990.

 180. James Haim BICHER MD, Wolfstein RS. Clinical use of regional hyperther­mia. Adv in Exp Med and Biol. Plenum Press, New York, 267: 1‑20, 1990.

 181. James Haim BICHER MD, Afuwape SA, Wolfstein RS, Bruley D, Reesman K. Tripas: A triple applicator system with relocatable "Hot spot" at tissue depth. Adv in Exp Med and Biol. Plenum Press, New York, 267: 327‑344, 1990.

 182. James Haim BICHER MD, Wolfstein RS. Local hyperthermia for superficial and moderately deep tumors. Factors affecting response. Adv in Exp Med and Biol. Plenum Press, New York, 267: 353‑367, 1990.

 183. James Haim BICHER MD, Wolfstein RS. Local hyperthermia for deep tumors. Adv in Exp Med and Biol. Plenum Press, New York, 267:411‑422, 1990.

 184. James Haim BICHER MD,Lung paper?  (Abstract). Proceeding of the 14th International Symposium on Clinical Hyperthermia (ICHS), Dubna, USSR, May 20-24, 1991.

 185. James Haim BICHER MD, Wolfstein RS.  Local Hyperthermic Treatment for Cancer in Aids Patients (Abstract).  Proceeding of the 9th International Congress of Radiation Research (ICRR). Toronto, Canada, July 7-12, 1991.

 186. James Haim BICHER MD, Mitagvaria, N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.

 187. Mitagvaria, N., James Haim BICHER MD. Local Blood Flow and PO2 in Rat's Brain During Maze Behavior (Abstract).  Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.

 188. James Haim BICHER MD, Wolfstein RS. Transcranial Treatment of Brain Tumors with Microwave Hyperthermia (Abstract).  Proceeding of the 8th Annual Conference of the American Society for Clinical Hyperthermic Oncology (ASCHO). Chicago, Illinois, October 31-November 2, 1991.

 189. James Haim BICHER MD, Wolfstein RS. Direct Relation Between Thermal Dose and Tumor Response in Hyperthermia Therapy (Abstract). Proceeding of the 77th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA).Chicago, Illinois. December 1-6, 1991.

 190. James Haim BICHER MD, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Paper presented as a poster). Proceeding of the 6th International Congress on Hyperthermic Oncology. Tucson, Arizona, April 26- May 1, 1992.

 191. James Haim BICHER MD, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the XV International Symposium on Clinical Hyperthermia (ICHS).  Lyon, France, May 19-22, 1992.

 192. James Haim BICHER MD, Wolfstein RS. Hyperthermia for Deep Tumors Analysis of Six Years Experience (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO).  Los Angeles, California, November 5-8, 1992.

 193. Surowiec, A. James Haim BICHER MD, Evaluation of Multiplane Sar Distribution of Hyperthermia Applicators by Means of Liquid-Crystal Card and Polyacrylamide Phantom System (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO).  Los Angeles, California, November 5-8, 1992.

 194. Surowiec, A. James Haim BICHER MD, Caridad, C. Vinh, F. Heating Characteristics of Tripas Systems (Abstract).  Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO).  Los Angeles, California, November 5-8, 1992.

 195. James Haim BICHER MD, Update on Hyperthermia Clinical Trials (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO).  Los Angeles, California, November 5-8, 1992.

 196.